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TMS Therapy allowed me to finally manage my depression instead of my depression managing me. TMS Therapy has given me freedom from depression.
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Virginia Beach, Va. – Rana Culotta Simpson has suffered from depression most of her adult life. “I would sleep three days, at times 2-3 days not getting out of the bed,” says Culotta. This made it hard for the 35-year-old Peninsula resident to keep her job as a newspaper reporter. “I was socially anxious. I was phobic, paranoid. It was very hard to focus,” says Culotta. She`d tried antidepressants, but she wasn`t getting better. Eventually, she was placed on work disability. Then she found Dr. Katharine Heatwole at Ocean Psychiatric Group in Virginia Beach. It’s one of only 2 or 3 clinics in Hampton Roads treating patients with transcranial magnetic stimulation or TMS. “It’s pulse magnetic energy to the front left part of the brain, and that stimulates a little electrical current to the neurons or brain cells,” says Dr. Heatwole. “During my 1st treatment, I actually felt like there was someone tinkering or tapping on my head,” says Culotta. “That has a stimulation effect on the mood circuit so that it releases the neurotransmitters that are involved in mood,” says Culotta. “It is based on neuroplasticity and training the neurons to do what they are supposed to do in […]
By the time she was 61, Martha Rhodes had spent decades battling intractable depression. Diagnosis: treatment-resistant major depressive disorder. She’d tried a variety of medications to no avail; most were ineffective or caused nausea, diarrhea, weight gain and mood swings. During one particularly low evening in 2009, she attempted suicide. And every morning when she awoke, she experienced what she describes as “an emotional nausea – it was like this feeling of, ‘Why am I still here? Why do I have to be alive?’” But four years ago, Rhodes, now 65, of Danbury, Connecticut, underwent a procedure she says saved her life: repetitive transcranial magnetic stimulation, which uses magnetic pulses to electrically stimulate nerve cells in the brain and is used by doctors to relieve symptoms of depression. “My feelings of hopelessness, wishing I were dead and that life wasn’t worth living – all of that went away,” recalls Rhodes, who chronicled her experience with TMS in her 2013 book “3,000 Pulses Later.” Rhodes says she shares her story with others to demystify the treatment – which is often misunderstood by both patients and doctors, though it’s increasingly used by medical practitioners nationwide. What Is TMS? TMS was first developed […]
So does Transcranial Magnetic Stimulation (TMS) work for those that are clinically depressed? Take a look at how it changed this man’s life.
Are you getting your depression treated? If not then it could be increasing your cardiovascular risk.
Learn about how this former NFL football player tackled his depression when traditional drug treatments failed
When you’re depressed, literally and figuratively stuck in a dark place, with no desire to get out and experience the world, it feels like time is inching by. Seconds feel like minutes, minutes feel like hours, and hours feel like days. Apparently, though, it’s not just a feeling. It’s a very real perception of time. New research from psychologists at the Johannes Gutenberg University of Mainz in Germany shows that depressed people actually experience time differently than healthy individuals. The scientists analyzed the results of 16 different studies examining 433 depressed subjects and 485 non-depressed control subjects. For the first part of the study, subjects were surveyed on their perception of time. “Psychiatrists and psychologists in hospitals and private practices repeatedly report that depressed patients feel that time only creeps forward slowly or is passing in slow motion,” reported study author Dr. Daniel Oberfeld-Twistel. The results of the meta-analysis confirmed that this is indeed the case. Then, for the second part of the study, they asked the subjects to subjectively estimate the length of a movie in minutes, press a button for five seconds, or identify the length of different sounds. In this case, the results obtained from the depressed […]
“A reduction of 20% or greater was considered significant.” [Read Full Article Here]
“The ketamine saved my life,” she says from her home. “Every time I think about it, I just want to cry.”
Researchers are launching a new trial to look into whether low doses of party drug ketamine can be used to treat alcoholics. The new study is recruiting volunteers to test whether low doses of ketamine help make psychological therapy more effective and prevent alcoholics from relapsing. A pilot study previously found that giving people doses of the drug as well as psychological therapy saw average 12-month relapse rates drop from 76% to 34%. Severe alcohol use affects nearly four million people in the UK. [Read the Full Article Here]
Australia and New Zealand start trials on the effects of Ketamine as an Anti-Depressant! This is huge in spreading the awareness of this as an incredibly effective treatment in treating depression.
“They say [ketamine] should always be treated as a medicine and not be placed under United Nations illicit drug restrictions The World Federation of Societies of Anaesthesiologists is calling for global support for its initiative to protect ketamine’s status as an essential medicine for anaesthesia and pain relief.” [Read Full Article Here]
Saturday September 10th, 2016 was World Suicide Prevention Day. This is such an important conversation to continue having everyday. In 2016, Ketamine has been found to “clear up the distraught thinking of people on the brink of suicide”. It’s giving hope to many people with severe depression that has resisted traditional antidepressants. “We’ll see what history has to say about the role of ketamine over a longer period of time, but as it stands now, ketamine is revolutionary.“ [Read Full Article Here]
“A new study in Biological Psychiatry reports that esketamine, a component of the general anesthetic ketamine, shows rapid and significant improvement in depressive symptoms in patients who do not respond to currently available therapies.” [Read Full Article Here]
“Ketamine is an essential anesthetic and painkiller, especially in countries with limited options and poor storage facilities in their hospitals,” said WFSA president Dr. Jannicke Mellin-Olsen” [Read Full Article Here]
Ketamine makes The Economist! “This is a change of direction so radical that some think it heralds a revolution in psychiatry.” [Read the Full Article Here]
An interesting article on the wide range of symptoms used to diagnose depression: “the standard rating scales used by healthcare professionals and researchers to diagnose this disease often differ in the symptoms they list, perhaps explaining why a one-size-fits-all treatment has to date been so ineffective.” [Read Full Article Here]
If you’re looking for information about ketamine from a scientific research perspective a terrific article was published in The Lancet and the information is still very descriptive and accurate. Click the link below to view the PDF. [Read Full Article Here]
“A recent review led by Matthew Cooper of Dalhousie University, Canada, in ‘The World Journal of Biological Psychiatry’ examined all peer-reviewed reports on the use of ketamine to treat depression. The evidence is a mix of small trials and individual case reports, but collectively they build a powerful picture.” [Read Full Article Here]
A fascinating article in The Atlantic that tells the story of a neuroscientist on a mission to change how the brain and immune system handle stress. Her work shows tremendous promise for the use of ketamine in treating PTSD and stress-related mental illness. [Read the Article Here]
Ketamine makes #7 on Dr. Axe’s Top 10 Medical Innovations to Watch Out for in 2017 list! “7. Ketamine for Treatment-Resistant Depression More than 15 millions Americans over the age of 18 suffer from depression — that’s 6.7 percent of the adult population. (8) And while there are some natural remedies and prescription medications available, for nearly one-third of depressed patients, they don’t work. Unfortunately, for about 43,000 people, the answer becomes suicide. The medical world believes there is new hope in ketamine for these extreme, treatment-resistant cases. For the last few years, the animal tranquilizer and sometimes-party drug has been studied and trialled as a treatment for major depression when other options have been exhausted, and the results are promising. Of course, I am an advocate for natural depression treatment and improving mood and brain structure through food and exercise, but in some cases, even that fails to work. Numerous studies have found that ketamine is extremely effective in treating major depression, sometimes as quickly as in 24 hours after just one dose. (9) Serial ketamine infusions seem to be even more effective at treating the mental disease. (10) It works by targeting and inhibiting NMDA receptors in nerve cells. Thanks to […]
When should you, the prescriber, conclude that your patient with depression is “treatment resistant,” and thereby eligible for alternative non-pharmacological interventions—such as vagus nerve stimulation (VNS), electroconvulsive therapy (ECT), or transcranial magnetic stimulation (TMS)? There are multiple ways that the failure to agree on a standardized definition of treatment-resistant depression (TRD) impacts the clinical care of patients who do not respond to multiple medication trials. In an article appearing in the January 2017 issue of JAMA Psychiatry, Charles Conway, M.D., Mark George, M.D., and Harold Sackheim, Ph.D., wrote that the lack of a consensus definition around what constitutes TRD “limits the ability to do comparative treatment research, to understand the biological underpinnings of TRD, and produces ambiguous medical insurance coverage issues.” Drawing on data from the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial, they proposed a definition for TRD: failure to respond to two trials of an antidepressant prescribed at an adequate dose for an adequate duration of time. Conway, a professor of psychiatry and director of the Treatment Resistant Depression and Neurostimulation Clinic at Washington University, St. Louis, said that in the absence of a consensus definition of TRD, patients often receive multiple trials of medication. “Our experience has been that […]
How Ketamine Could Cure Depression The major excitatory neurotransmitter in the central and peripheral nervous system, glutamic acid, has been known for more than 50 years to produce its actions through various ionotropic channels (NMDA and AMPA) and G-coupled metabotropic receptors (mGluR 1 to 5). The glutamate-sensitive ion channels comprise multiple protein subunits and are subject to many regulatory and modulatory controls. Such intrinsic mechanisms are most apparent in the N-methyl D-aspartate (NMDA) receptor-operated ion channel which, in turn, offers countless opportunities for drugs to selectively exploit the ubiquity of glutamate’s excitatory role. Discovery of NMDA antagonists Considerable discovery efforts in the early 90s targeted various components of the NMDA receptor complex with the aim of developing new treatments for neurodegeneration – Alzheimer’s, Parkinson’s, Huntington’s diseases, stroke, traumatic brain injury – as well as epilepsy and pain, with some interest directed to psychiatric indications like anxiety. When the undesirable CNS side effects of many of these new drug candidates became apparent much of this research was curtailed, although several compounds with weak, or non-selective effects on the NMDA receptor were subsequently approved e.g. memantine, adamantine, methadone, and dextromethorphan. Return of the NMDA antagonist – the Ketamine breakthrough Targeting NMDA receptors came back into […]
WENCY LEUNG The Globe and Mail Published Thursday, Feb. 16, 2017 3:23PM EST Last updated Thursday, Feb. 16, 2017 5:18PM EST Inspired by promising research into ketamine’s therapeutic effects, people are swapping strategies online on how to use the drug to ease their despair. Could ‘Special K’ be a panacea for depression? Wency Leung reports John woke up one morning feeling almost like his old self. He got out of bed, took a shower and, for the first time in a long time, felt as though this day would not be his last. His suicidal thoughts had faded overnight. The previous morning, the 50-year-old Ottawa father of three was given his first intravenous infusion of the drug ketamine as part of a trial for people with treatment-resistant depression. John (not his real name) had tried various medications for his depression over the years – without improvement. But within hours of receiving his first ketamine infusion, he began feeling better. “I started feeling the benefits almost right away,” he said. By the next morning, “not completely, but I felt like I could behave like the normal man that I used to be.” [Read More]
A Very Moving and Well Written Account from a Healthcare Professional and Parent As both a healthcare professional and a parent of a child who suffers from treatment resistant depression and anxiety, I have been quite attentive to the changes that arise in an individual after receiving low-dose ketamine. I thought it would be helpful to share my observations with others who are contemplating offering this innovative treatment in their practices or for those that may be exploring ketamine as an option in treating their own depression. Though low-dose ketamine can alleviate suicidal thoughts immediately and lift an individual from feelings of despair which many have suffered for years, it does not cure one’s depression indefinitely. Ketamine, in my experience, has worked in a way that it offers hope to individuals and provides a new found resilience in dealing with life stressors. As an outsider looking in, I have watched my child develop the drive and passion to discover new approaches to help improve her mental health and overall well-being. I have been quite focused on my child’s state of mental health since her return back to college and found that the negative thoughts and depression started to creep back […]
Depressive Symptoms Associated With Aggression Violence is not usually considered to be related to depression, yet findings suggest an association between violent behavior and depression or depressive symptoms in many different disorders. A Swedish study compared the criminal records of 47,158 depressed individuals with the records of 898,454 people with no history of depression matched by age and sex.1 Those in the depressed group were approximately 3 times more likely than the general population to commit violent crimes, such as homicide, attempted homicide, aggravated assault, or robbery. This association was present even when previous histories of violence, self-harm, psychosis, and substance use were taken into consideration. Furthermore, the risk of violent crime significantly increased in individuals with more depressive symptoms. [Read the Full Article Here]
Ketamine the Next-Gen Treatment “There are key questions right now concerning both the scientific understanding of ketamine and the potential future use of ketamine or ketamine-like drugs for depression,” Dr Murrough told Medscape Medical News. One question is how ketamine triggers an antidepressant response within 1 day, whereas conventional antidepressants require 2 weeks or longer to take effect. “What is the biological basis of ketamine’s antidepressant mechanism of action?” he asked. It also remains a mystery why ketamine is successful in treating symptoms of depression in patients who have not responded to conventional treatments. “What can ketamine do in the brain that is relevant to the treatment of depression, that current antidepressant drugs do not do?” asked Dr Murrough. [Read the Full Article Here]
“Special K,” a psychedelic drug popular in dance clubs, is being used to treat severe depression when nothing else works. [Read the Original Article Here]
Several research teams around the world have been trialing ketamine use in chronic and recurring depression Thomson Reuters Posted: Apr 06, 2017 5:04 PM ET Last Updated: Apr 06, 2017 5:15 PM ET The party drug ketamine can have powerful beneficial effects on severely depressed patients who have struggled for years to recover, and the drug should be developed responsibly as a psychiatric medicine, British experts said on Thursday. In a study published in the Lancet Psychiatry journal, specialists from Oxford University said there is an urgent need for ethical and innovative action by doctors to prescribe the drug under controlled conditions. “We think patients’ treatment should be in specialist centers and formally tracked in national or international registries,” said Rupert McShane, a consultant psychiatrist and researcher at Oxford who has led a series of ketamine studies. [Read the Full Article Here]
One patient says drug slows down the ‘constant, overwhelming bombardment of negative intrusive thoughts surging through your brain’ Katie Forster Health Correspondent @katieforster Ketamine can provide relief to patients with severe depression “where nothing has helped before”, researchers calling for a new approach to the drug’s medical use have said. For six years, scientists from Oxford University have been using ketamine to treat more than 100 people with treatment-resistant depression. They said patients who received a series of carefully administered intravenous infusions of the drug, followed by oral top-ups, showed sustained improvement in around 40 per cent of cases – a significant result when other antidepressants have failed. “There are lots of people who are currently resistant to antidepressant drugs and psychotherapies,” consultant psychiatrist Rupert McShane told The Independent. “We’d like to see some more centers developing expertise [about ketamine] and starting to use it.” [Read the Full Article Here]
Ketamine, introduced in 1966 as an anesthetic, is increasingly showing up in private clinics nationwide as a treatment for chronic pain. While the drug is indeed a potent pain reliever, its effect is short-lived; and use may be accompanied by headache, nausea, and fatigue, among other adverse outcomes. There also is a risk of abuse given ketamine’s euphoric properties, which have earned it a reputation as a club drug. For these and other reasons, clinicians are apprehensive about pain centers administering off-label ketamine infusions for conditions ranging from fibromyalgia to migraines. The jury is still out, they say, on whether ketamine is a viable option for pain management. While some studies have reported a benefit, the quality of the evidence is low due to the small scale, limited generalization, and lack of effective blinding in these investigations. Moreover, research evaluating ketamine for chronic pain has focused on I.V. infusion, which inflates the cost of treatment and limits its use over the long term. The American Society of Regional Anesthesia and Pain Medicine is expected to issue guidelines on ketamine use for pain management within 6 months, but University of Pittsburgh anesthesia and psychiatry professor Ajay Wasan, MD, says clinicians will […]
Over the past 15 years the treatment of Depression and related illnesses has undergone a myriad of changes. A milestone that had a significant impact was the effective use of Genomic testing that assisted in utilizing psychotropic medications in a systematic and scientific fashion. Here, the experience of the physicians was augmented by the genetic information about the patient and a better decision was reached in selecting the proper medication(s). This often resulted in a larger number of patients reaching greater degrees of emotional stability more rapidly and with fewer untoward effects. It has been noted that approximately 75% of patients can now reach a state of remission. The World Health Organization has stated that over 350 million people in the world suffer from Depression. In the United States in 2012, the NIMH (National Institute of Mental Health) reported 6.9% of the population (16 million) suffered from at least one major episode of Depression. If you factor in those suffering from the depressive aspects of PTSD, Chronic Pain, Bipolar Disorders and Post Partum Disorders, these numbers drastically increase. Early diagnosis and scientifically based treatment can facilitate successful treatment to reach or surpass the 75% referenced above. The remaining 25% are […]
Jesse Tahirali, CTVNews.ca Published Sunday, January 25, 2015 10:10PM EST The grey clouds of depression are difficult to shake. Approximately eight per cent of Canadian adults will experience a major depression at some point in their lives, according to Toronto’s Centre for Addiction and Mental Health. Medication often fails to temper the debilitating effects of the illness. Only one third of patients report improvement after their first round of treatment, and some fail to improve regardless of what they’re prescribed. Gail Bellissimo, a Mississauga mother of four, was one of those people who still suffer even after seeking help. “I tried just about every drug out there, antidepressant of all kinds,” Bellissimo said. “They just either didn’t work for me or the side effects were too much for me to take.” But after years of living through the lows, Bellissimo said it only took three minutes to pick her up out of her depression. She was driving home when her new treatment began to take effect. “It was so unnerving at first,” she said. “At first it was like, “Wow, is this what it feels like to be normal?’” Bellissimo participated in a four-week study for something called theta-burst stimulation, […]
The FDA recently granted 510k clearance to market MagVita TMS therapy, a repetitive transcranial magnetic stimulation system, for treatment of depression. “The new FDA cleared MagVita TMS Therapy system is tailor-made for health care professionals seeking an entry-level TMS system without having to compromise on quality and safety,” Kerry Rome, BS, vice president of sales at MagVenture Inc, said in a press release. The MagVita TMS therapy system was first cleared by the FDA in 2015 for treatment of major depressive disorder. [Read the Full Press Release Here]
Analysis of FAERS data finds less comorbid depression among pain patients on ketamine by Neel A. Duggal Contributing Writer, MedPage TodayMay 12, 2017 An analysis of data from the FDA Adverse Events Reporting System (FAERS) supported previous findings that ketamine could be an effective treatment for depression, researchers found. Given financial and ethical obstacles to a large randomized controlled trial of ketamine for depressive disorders, Ruben Abagyan, PhD, of the University of California San Diego, and colleagues decided to turn to AERS data on patients taking ketamine for pain, an FDA-approved use. They found that patients who took ketamine had significantly lower frequency of reports of depression than those taking any other drugs for pain, according to findings published in Scientific Reports. “This reduction in depression is specific to ketamine and is known to be much more rapid than current antidepressants, making this observed effect very promising for treatment of patients with acute depressive or suicidal episodes,” Abagyan and colleagues wrote. [Read the Full Article Here]
Shape Magazine Recently Covered Ketamine as a Depression Treatment By Rachel Jacoby Zoldan | May 16, 2017 Depression is more common than you might think. It affects more than 15 million Americans, and the World Health Organization estimates that number grows to 300 million when you expand globally. There are a slew of different treatment options available to help alleviate its symptoms—think anxiety, insomnia, fatigue, and loss of appetite among others—with the most common treatment being serotonin reuptake inhibitors (or SSRIs). But since about 2000, doctors and researchers have been experimenting with ketamine—originally a pain management pharmaceutical, now abused as a street drug because of its hallucinogenic effects—as another potential way to treat the condition, according to Ruben Abagyan, Ph.D., a pharmacology professor at the University of California San Diego (UCSD). You’re probably thinking, “Wait! What?” If you’ve heard of ketamine, also known as Special K, you know it’s no joke or generic OTC drug. In fact, it’s known as a dissociative anesthetic (meaning a drug that distorts perception of sight and sound, while producing literal feelings of detachment from the self and the environment). It’s primarily used by veterinarians for treating pain in animals, but it can also be […]
There’s More Proof That Ketamine Works for Depression For decades, scientists have searched for a new type of antidepressant, one that works differently from the 20-plus drugs already on the market. Finding a new option is crucial, since a third of people don’t respond to available depression treatments. They haven’t had much luck — except for the discovery that IV infusions of ketamine hydrochloride, an FDA-approved anesthetic, can cause rapid antidepressant effects in many people with stubborn depression. Figuring out exactly how ketamine has these effects has been a researcher’s dream, since ketamine is too problematic a drug to currently be considered a mainstream depression treatment. It’s illicitly used — and abused — as a psychedelic club drug and can cause hallucinations. Ketamine can also have negative side effects when used off-label to treat depression, including unexpected changes in heart functioning, cognition and respiration. Its antidepressant effects fade, so it typically has to be given over and over again, and it’s not yet clear how safe or effective it is when taken long-term. Developing a drug that works like ketamine, but without all the baggage, is the holy grail — but scientists haven’t known quite what to target. Now, in […]
Scientists have identified a key protein that helps trigger ketamine’s rapid anti-depressant effects in the brain, a crucial initial step to developing alternative treatments to the controversial drug being dispensed in a growing number of depression clinics across the country. Ketamine is drawing intense interest in the psychiatric field after multiple studies have demonstrated it can quickly stabilize severely depressed patients. But ketamine – illicitly used for its psychedelic properties – could also impede memory and other brain functions, spurring scientists to identify new drugs that would safely replicate its anti-depressant response without the unwanted side effects. A new study from the Peter O’Donnell Jr. Brain Institute has jumpstarted this effort in earnest by answering a question vital to guiding future research: What proteins in the brain does ketamine target to achieve its effects? “Now that we have a target in place we can research the pathway and develop drugs that safely recreate the anti-depressant effect,” said Dr. Lisa Monteggia, Professor of Neuroscience at UT Southwestern Medical Center’s O’Donnell Brain Institute. The study published in Nature shows that ketamine blocks a protein responsible for a range of normal brain functions. The blocking of the N-methyl-D-aspartate (NMDA) receptor creates the initial […]
PASWFL’s New Treatments for Depression Showcased on ABC TV Show PASWFL was featured on Out and About Southwest Florida. We had a chance to film and take photos of our beautiful facility as well as discuss the different treatment options we’re proud to offer people in Southwest Florida and surrounding communities. Check out the video tour of our office below: And more images of our comfortable treatment rooms:
LOS ANGELES, July 11 — Doctors in California say magnetic stimulation can help ‘rewire’ the brains of people withdepression, offering hope for patients whose condition is not improved by medication or therapy. Depression is one of the most common forms of mental illness, affecting more than 350 million people worldwide. Bob Holmes is one of them. “I struggled with that for many years, didn’t know really what to do, tried to pull myself through it. And then ultimately when I got into my forties, I wasn’t successful.” Holmes has been receiving transcranial magnetic stimulation at the University of California Los Angeles, a treatment that beams targeted magnetic pulses deep inside his brain. Doctors say the therapy can effectively ‘rewire’ the brain by changing how brain circuits are arranged. Reuters Video: Doctors hope to ‘rewire’ depressed people’s brains: [Read the Full Article Here]
Ketamine has ‘truly remarkable’ effect on depression and is effective in elderly patients, scientists say. After six months, 43% of the subjects said they had no significant symptoms of depression. Katie Forster Health Correspondent @katieforster Wednesday 26 July 2017 08:38 BST Ketamine can have a “truly remarkable” effect on people with depression, researchers have said after a new study showed promising results among elderly patients. Colleen Loo, a professor at the University of New South Wales in Australia, led the world’s first randomised control trial into the drug’s effect on people over 60 with treatment-resistant depression. “This trial has shown ketamine can be used safely in the elderly and it tends to be effective,” she told The Independent, adding that a similar effect was observed in this age group as in younger patients. It is important to test how people of different ages respond to a new treatment before it can be offered by doctors, she said: “Sometimes depression in the elderly can be harder to treat, especially with medication. “Also, they tend to have more medical problems, which can interfere with medication.” Ketamine was discovered in 1962 and is licenced for medical use in the UK as an anaesthetic, but is also used […]
New Hope for Depression Mandy Oaklander Jul 26, 2017 TIME Health For more, visit TIME Health. Every week, when Ian Hanley sits down with his therapist, he goes through a list of depression treatments he’s been researching online. The best-known treatments at the top of the list–half a dozen antidepressants and known combinations of those drugs–are all crossed out. “My therapist says he’s never had this much difficulty with somebody,” says Hanley, “which is sort of a dubious honor.” Hanley is only 21 years old, but he’s already six years into his search for something, anything, that can help him feel better for more than a few weeks at a time. “I’ve heard people describe it as sadness, and that’s not specific enough,” he says. Numbness is closer, but it’s not like depression inures you to suffering. “It’s like not quite being alive,” he says, “but still having to go through all the crappy parts of being alive.” When he was in the 10th grade, Hanley basically lost all desire to get out of bed in the morning. He started seeing a psychiatrist and a therapist–the same one he sees today–and went on Zoloft. “I wasn’t catatonic anymore,” he says. But […]
Patrice Wendling August 03, 2017 MURRAY, UT — Depression and coronary artery disease are known to walk hand in hand, but a new study suggests that depression any time after a diagnosis of CAD is the strongest predictor of death. Among 24,137 patients identified with significant CAD, a new depression diagnosis was associated with a twofold higher risk of all-cause death after multivariable adjustment, the investigators reported in the European Heart Journal Quality of Care and Clinical Outcomes. “It was stronger than any follow-up events, stronger than diabetes, stronger than smoking, sex, prior diagnosis of high blood pressure or depression, and even whether they had a heart attack,” lead author Dr Heidi T May (Intermountain Heart Institute, Murray, UT) told theheart.org | Medscape Cardiology. “I thought it would be a significant predictor, but I didn’t anticipate it would be the strongest. “I would think most people would find that amazing.” She said the results emphasize the need for continual depression screening among all CAD patients, but an accompanying editorial notes that recommendations by the American Heart Association (AHA) for routine screening in patients with heart disease have been met with some opposition, in large part because of a lack of studies showing a survival benefit with depression treatment. “Given the […]
By Meredith WadmanAug. 29, 2017 , 3:30 PM Luca Rossi tried to hang himself in a bedroom in Perugia, Italy, in 2012. Suspended by his belt from a wardrobe, he had begun to choke when his fiancée unexpectedly walked in. He struggled to safety, defeated even in this intended last act. The 35-year-old physician had everything to live for: a medical career, plans for a family, and supportive parents. But Rossi* was addicted to crack cocaine. He had begun his habit not long after medical school, confidently assuming that he could control the drug. Now, it owned him. Once ebullient and passionate, he no longer smiled or cried. He knew he might be endangering his patients, but even that didn’t matter. He was indifferent to all except obtaining his next fix. “It pushes you to suicide because it fills you with your own emptiness,” he says. In the first months after his near suicide, Rossi didn’t drop his $3500-a-month habit. Early in 2013, he learned that his fiancée was pregnant. Frightened by impending fatherhood, he smoked even more. He didn’t—couldn’t—stop. Then, in April 2013, Rossi’s father, a chemist, happened upon a local newspaper article describing work just published in Nature. […]
Dr. Robert Pollack, MD is excited to announce that he has just been appointed to the Clinical Research Faculty for the Clinical and Translational Genome Research Institute.
William Storey remembers a childhood filled with hopelessness and loneliness instead of birthday parties and bike rides. “I was abnormal at an age in which abnormality is very unhealthy,” states William, now 23. The abrupt and dramatic cultural change caused by his family’s move from Maine to Georgia when he was eight complicated the challenges William already faced. Over the years, he’s been diagnosed with attention deficit hyperactivity disorder, bipolar disorder, severe depression and Asperger’s syndrome, a higher – functioning form of autism. Generally, Asperger’s patients struggle to communicate with and relate to others. They may lack empathy and have difficulty reading other people’s moods and making friends. During his early years in private school, William felt isolated and misunderstood, especially by classmates, and by teachers who disciplined him for “being out of control.” He explains the mindset of those teachers this way: “I like to think of it as, This nail doesn’t seem to be fitting into this particular piece of wood quite the same way the rest of them do, so we should probably hit it more.” By the time he reached fourth grade, William wanted to die. “I hated my life,” he recalls. “I hated everything.” In […]
Post-Traumatic Stress Disorder (PTSD) has a reputation for being difficult to treat, especially in active duty military and veteran populations. That may soon change, according to research findings shared Wednesday at the 2017 San Antonio Combat PTSD Conference. There are two medications approved by the Food and Drug Administration to treat PTSD: Zoloft and Paxil. Both are part of a class of antidepressants known as selective serotonin reuptake inhibitors. They’re only modestly effective and take about 10 weeks to set in. Outcomes have been poor in military and vet populations, particularly in people with chronic, multi-trauma PTSD. A new kind of treatment is gaining traction. It’s ketamine, a medication mainly used to start and maintain anesthesia. On Wednesday a group of leading researchers gathered at the San Antonio Combat PTSD Conference, presented by STRONG STAR and the Consortium to Alleviate PTSD, two programs of UT Health San Antonio. Dr. John Krystal, Chair of the Psychiatry Department at Yale University, studies ketamine’s effects on the brain. In his keynote address, Krystal said that ketamine works fast to relieve symptoms of depression in trials, with some patients showing a complete turnaround after just one intravenous dose. “This idea of people with chronic, treatment resistant depression–multiple treatments: psychotherapies, […]