“Depression researchers at Black Dog Institute and University of NSW had to abort a “promising” pilot trial into the efficacy of ketamine nasal sprays after patients experienced psychotic-like effects and temporary loss of fine motor skills.

The researchers were hopeful the trial would work as an earlier study in the US had shown ketamine – an anaesthetic drug shown to have rapid antidepressant effects – could be safely delivered using a nasal spray.

But in a paper published in the latest Journal of Psychopharmacology, the research team, led by Professor Colleen Loo, said they had to stop the trial at five participants with severe depression (they were aiming for 10) because of unexpected side effects – their blood pressure shot up, they became uncoordinated and they suffered “unpleasant” psychotic-like effects.”

The quote above is an exerpt from an article in the Sydney Morning Herald. To read the full article please click HERE. To read the original study in the Journal of Psychopharmacology that the Sydney morning herald is discussing, please click HERE.