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Effectiveness of theta burst versus high-frequency repetitive transcranial magnetic stimulation in patients with depression (THREE-D): a randomised non-inferiority trial

Background Treatment-resistant major depressive disorder is common; repetitive transcranial magnetic stimulation (rTMS) by use of high-frequency (10 Hz) left-side dorsolateral prefrontal cortex stimulation is an evidence-based treatment for this disorder. Intermittent theta burst stimulation (iTBS) is a newer form of rTMS that can be delivered in 3 min, versus 37·5 min for a standard 10 […]

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Intranasal Esketamine Succeeds in Depression Trial

Intranasal Esketamine Succeeds in Depression Trial

4-point cut in MADRS scores versus placebo after 4 weeks by Kristen Monaco, Staff Writer, MedPage TodayMay 09, 2018 NEW YORK CITY — Intranasal esketamine paired with an oral antidepressant improved symptoms of treatment-resistant depression, researchers reported here. When compared to intranasal placebo plus an antidepressant, two phase III studies found twice-weekly flexibly-dosed intranasal esketamine added to […]

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Ketamine: A depression drug that researchers have called ‘the most important discovery in half a century’ just got a big lift

Ketamine: A depression drug that researchers have called ‘the most important discovery in half a century’ just got a big lift

Ketamine, which has been called “the most important discovery in half a century,” just got a step closer to becoming the first new depression drug in 35 years. Johnson & Johnson, one of the pharmaceutical companies pursuing the drug’s fast-acting antidepressant qualities, presented some promising new research on Saturday that could raise the drug’s profile as a potential treatment for […]