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Unlocking the Mysteries of the Glutamate System

Unlocking the Mysteries of the Glutamate System

Ketamine, Similar Compounds Emerging as Mood Disorder Treatments Sanjay J. Mathew, MD, vice chair for research at Baylor College of Medicine and staff physician at the Michael E. Debakey VA Medical Center in Houston, Texas, has long been interested in the brain’s glutamate system and how it could be manipulated with substances such as ketamine to […]

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US health officials report new vaping deaths, repeat warning

US health officials report new vaping deaths, repeat warning

NEW YORK (AP) — U.S. health officials on Friday again urged people to stop vaping until they figure out why some are coming down with serious breathing illnesses. Officials have identified about 450 possible cases, including as many as five deaths, in 33 states. The count includes newly reported deaths in California, Indiana and Minnesota. […]

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Trial of SAGE-217 in Patients with Major Depressive Disorder

Trial of SAGE-217 in Patients with Major Depressive Disorder

Handan Gunduz-Bruce, M.D.,  Christopher Silber, M.D.,  Inder Kaul, M.D.,  Anthony J. Rothschild, M.D.,  Robert Riesenberg, M.D.,  Abdul J. Sankoh, Ph.D.,  Haihong Li, Ph.D.,  Robert Lasser, M.D.,  Charles F. Zorumski, M.D.,  David R. Rubinow, M.D.,  Steven M. Paul, M.D.,  Jeffrey Jonas, M.D.,  et al. Abstract BACKGROUND Altered neurotransmission of γ-aminobutyric acid (GABA) has been implicated in […]

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Adjunctive Riluzole Shows Promise in Treatment-Resistant Depression

Adjunctive Riluzole Shows Promise in Treatment-Resistant Depression

The glutamate blocker riluzole may have longer-term beneficial effects as adjunctive treatment for some patients with treatment-resistant depression, according to results of a trial published in the Journal of Affective Disorders. The US Food and Drug Administration approved riluzole for the treatment of amyotrophic lateral sclerosis in 1994. It inhibits presynaptic release of glutamate and acts directly […]

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Frequent Use of Medications for Sleep May Increase Dementia Risk, Especially Among Older White Adults

Frequent Use of Medications for Sleep May Increase Dementia Risk, Especially Among Older White Adults

Frequent use of sleep medications appears to be associated with increased long-term risk of dementia, particularly among older white adults, according to research presented at the Alzheimer’s Association International Conference in Los Angeles this week. “Based on our findings, we recommend that clinicians make more effort to be aware of their patients’ sleep problems including […]

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Anxiety Prevalent in First-Episode Major Depressive Disorder

Anxiety Prevalent in First-Episode Major Depressive Disorder

Anxiety is a common comorbidity among drug-naive individuals with first-episode major depressive disorder, according to cross-sectional study data published in the Journal of Affective Disorders. Patients were recruited from the psychiatric department of a general hospital in Taiyuan, China. Drug-naive individuals receiving outpatient care and reporting first-episode major depressive disorder were eligible for inclusion. Demographic and clinical […]

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Antidepressant Adherence Linked to Increased Survival in Patients With Cancer, Study Finds

Antidepressant Adherence Linked to Increased Survival in Patients With Cancer, Study Finds

A study published this week in Depression & Anxiety suggests that among patients with cancer who are prescribed antidepressants, those who take the medication may live longer than those who are non-adherent. Patients with cancer are known to have higher rates of depression than the general public—a factor that may reduce adherence to cancer treatment and increase their […]