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Anxiety Prevalent in First-Episode Major Depressive Disorder

Anxiety Prevalent in First-Episode Major Depressive Disorder

Anxiety is a common comorbidity among drug-naive individuals with first-episode major depressive disorder, according to cross-sectional study data published in the Journal of Affective Disorders. Patients were recruited from the psychiatric department of a general hospital in Taiyuan, China. Drug-naive individuals receiving outpatient care and reporting first-episode major depressive disorder were eligible for inclusion. Demographic and clinical […]

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Antidepressant Adherence Linked to Increased Survival in Patients With Cancer, Study Finds

Antidepressant Adherence Linked to Increased Survival in Patients With Cancer, Study Finds

A study published this week in Depression & Anxiety suggests that among patients with cancer who are prescribed antidepressants, those who take the medication may live longer than those who are non-adherent. Patients with cancer are known to have higher rates of depression than the general public—a factor that may reduce adherence to cancer treatment and increase their […]

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Estimates of Adult Benzodiazepine Use Double

Estimates of Adult Benzodiazepine Use Double

Baby boomers match seniors in the use of benzodiazepines, while misuse is most common in those aged 18 to 25. Over 30 million U.S. adults took benzodiazepines in the past year, including 5.3 million who misused the medication, according to a study posted December 17, 2018, in Psychiatric Services in Advance. The findings, which were based […]

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How Pharmacogenomics Can Help Patients with Treatment-Resistant Depression

How Pharmacogenomics Can Help Patients with Treatment-Resistant Depression

Treatment-resistant depression can be a frustrating challenge for doctor and patient alike. The trial-and-error process of trying different medications and treatments to see what alleviates patients’ depression symptoms can feel like a “shot in the dark” approach. According to Ann McDonald, former editor of the Harvard Mental Health Letter, in her blog post on the Harvard […]

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Treatment of fibromyalgia in adults not responsive to initial therapies

Treatment of fibromyalgia in adults not responsive to initial therapies

INTRODUCTION Fibromyalgia is a chronic pain disorder that is often difficult to treat. Effective interventions include a number of nonpharmacologic and pharmacologic therapies that are often provided in combination. Patients with fibromyalgia generally respond best to a multidisciplinary, individualized treatment program that incorporates the primary treating clinician and other healthcare providers, including physical medicine, rehabilitation, […]

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Post Traumatic Stress Disorder and Binge Eating Disorder, What is the Link and Treatment

Post Traumatic Stress Disorder and Binge Eating Disorder, What is the Link and Treatment

Post Traumatic Stress Disorder is a psychiatric disorder that is a direct consequence of experiencing trauma. Experiencing war, working in emergency response areas, sexual, emotional or physical abuse, a threat of death, even childhood neglect can cause changes in the brain. Also, if the traumatic event did not happen to you directly and you were a […]

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Treatment-Naive Women Commonly Over-prescribed Zolpidem

Treatment-Naive Women Commonly Over-prescribed Zolpidem

The use of higher-than-recommended doses of zolpidem was commonly seen in women not previously treated with the drug, according to results from a study published in the Journal of Clinical Psychiatry. Researchers conducted a retrospective cohort study of 139,525 people who had never been treated with zolpidem and were prescribed the drug from January 1, 2013, […]

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Mild Depression Predictive of All-Cause Mortality After MI

Mild Depression Predictive of All-Cause Mortality After MI

Mild depression was a long-term independent predictor of death in patients after acute myocardial infarction (AMI), per cohort study data published in Heart, Lung and Circulation. Investigators conducted a 25-year follow-up of men who were recruited after AMI to participate in a randomized controlled trial in the 1980s. The initial trial investigated the impact of high intensity exercise […]

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The Psychopharmacology of Depression: Strategies, Formulations, and Future Implications

With well over two dozen traditional antidepressants available in the US, and an ever-growing list of other psychotropic compounds with apparent antidepressant properties, pharmacological options for treating clinical depression today are broad and vast. However, recent findings suggest that the magnitude of efficacy for most antidepressants compared with placebo may be more modest than previously […]

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Neuroplasticity and the next wave of antidepressant strategies

Abstract Depression is a common chronic psychiatric disorder that is also often co-morbid with numerous neurological and immune diseases. Accumulating evidence indicates that disturbances of neuroplasticity occur with depression, including reductions of hippocampal neurogenesis and cortical synaptogenesis. Improper trophic support stemming from stressor-induced reductions of growth factors, most notably brain derived neurotrophic factor (BDNF), likely […]