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The Effects of Chronic Stress On Your Mental Wellness

The Effects of Chronic Stress On Your Mental Wellness

Let’s face it: we’re all stressed these days. In fact, recent polls show just how stressed out Americans are over things like politics, work, finances … the list goes on and on. It seems like we’ve adopted a new work culture where the 8-hour workday is a thing of the past. People are working 9 […]

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Unlocking the Mysteries of the Glutamate System

Unlocking the Mysteries of the Glutamate System

Ketamine, Similar Compounds Emerging as Mood Disorder Treatments Sanjay J. Mathew, MD, vice chair for research at Baylor College of Medicine and staff physician at the Michael E. Debakey VA Medical Center in Houston, Texas, has long been interested in the brain’s glutamate system and how it could be manipulated with substances such as ketamine to […]

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Trial of SAGE-217 in Patients with Major Depressive Disorder

Trial of SAGE-217 in Patients with Major Depressive Disorder

Handan Gunduz-Bruce, M.D.,  Christopher Silber, M.D.,  Inder Kaul, M.D.,  Anthony J. Rothschild, M.D.,  Robert Riesenberg, M.D.,  Abdul J. Sankoh, Ph.D.,  Haihong Li, Ph.D.,  Robert Lasser, M.D.,  Charles F. Zorumski, M.D.,  David R. Rubinow, M.D.,  Steven M. Paul, M.D.,  Jeffrey Jonas, M.D.,  et al. Abstract BACKGROUND Altered neurotransmission of γ-aminobutyric acid (GABA) has been implicated in […]

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Adjunctive Riluzole Shows Promise in Treatment-Resistant Depression

Adjunctive Riluzole Shows Promise in Treatment-Resistant Depression

The glutamate blocker riluzole may have longer-term beneficial effects as adjunctive treatment for some patients with treatment-resistant depression, according to results of a trial published in the Journal of Affective Disorders. The US Food and Drug Administration approved riluzole for the treatment of amyotrophic lateral sclerosis in 1994. It inhibits presynaptic release of glutamate and acts directly […]

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Antidepressant Adherence Linked to Increased Survival in Patients With Cancer, Study Finds

Antidepressant Adherence Linked to Increased Survival in Patients With Cancer, Study Finds

A study published this week in Depression & Anxiety suggests that among patients with cancer who are prescribed antidepressants, those who take the medication may live longer than those who are non-adherent. Patients with cancer are known to have higher rates of depression than the general public—a factor that may reduce adherence to cancer treatment and increase their […]

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How Pharmacogenomics Can Help Patients with Treatment-Resistant Depression

How Pharmacogenomics Can Help Patients with Treatment-Resistant Depression

Treatment-resistant depression can be a frustrating challenge for doctor and patient alike. The trial-and-error process of trying different medications and treatments to see what alleviates patients’ depression symptoms can feel like a “shot in the dark” approach. According to Ann McDonald, former editor of the Harvard Mental Health Letter, in her blog post on the Harvard […]

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Mild Depression Predictive of All-Cause Mortality After MI

Mild Depression Predictive of All-Cause Mortality After MI

Mild depression was a long-term independent predictor of death in patients after acute myocardial infarction (AMI), per cohort study data published in Heart, Lung and Circulation. Investigators conducted a 25-year follow-up of men who were recruited after AMI to participate in a randomized controlled trial in the 1980s. The initial trial investigated the impact of high intensity exercise […]

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The Psychopharmacology of Depression: Strategies, Formulations, and Future Implications

The Psychopharmacology of Depression: Strategies, Formulations, and Future Implications

With well over two dozen traditional antidepressants available in the US, and an ever-growing list of other psychotropic compounds with apparent antidepressant properties, pharmacological options for treating clinical depression today are broad and vast. However, recent findings suggest that the magnitude of efficacy for most antidepressants compared with placebo may be more modest than previously […]