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WITHOUT REMISSION, THE BURDEN OF MDD GROWS

For 50 years, pharmacological treatment approaches in MDD have focused on targeting monoamine receptors in the hopes of reducing symptoms. While conventional therapies have helped many, the STAR*D trial* revealed that as many as a third of patients may not achieve remission despite treatment with traditional antidepressants.¹,² Dr Rakesh Jain, clinical professor of psychiatry at […]

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Brexanolone Infusion Rapidly Relieves Postpartum Depression

Brexanolone Infusion Rapidly Relieves Postpartum Depression

NEW YORK (Reuters Health) – A 60-hour infusion of brexanolone significantly improves symptoms in women with postpartum depression, according to results from two phase 3 trials. The results “confirm and extend the previous work showing that brexanolone has a rapid onset of action that is unlike anything else currently available,” said Dr. Samantha Meltzer-Brody from […]

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A Deeper Understanding of Major Depressive Disorder is Within Reach

A Deeper Understanding of Major Depressive Disorder is Within Reach

WHY AREN’T SOME PATIENTS WITH MDD REACHING REMISSION? For more than 50 years, major depressive disorder (MDD) pharmacological treatment approaches have focused on increasing the level of monoamine neurotransmitters in the brain, with the hope of reducing symptoms.1 And while conventional antidepressants have helped most, the STAR*D trial* found that one-third of patients didn’t achieve remission after multiple treatment […]

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Acetyl-l-carnitine deficiency in patients with major depressive disorder

Acetyl-l-carnitine deficiency in patients with major depressive disorder

Significance Identifying biological targets in major depressive disorder (MDD) is a critical step for development of effective mechanism-based medications. The epigenetic agent acetyl-L-carnitine (LAC) has rapid and enduring antidepressant-like effects in LAC-deficient rodents. Here, we found that LAC levels were decreased in patients with MDD versus age- and sex-matched healthy controls in two independent study […]

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Sources of Parent-Offspring Resemblance for Major Depression

Sources of Parent-Offspring Resemblance for Major Depression

Question: How do effects of genetics and rearing each contribute to the transmission of risk for major depression from parents to children?   Findings: In this population register–based study of 2 269 552 offspring of intact, adoptive, not-lived-with father, stepfather, and triparental families from the general Swedish population, the effects of genes and rearing were […]

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Could treating depression worsen symptoms in the long run?

Could treating depression worsen symptoms in the long run?

Published Thursday 26 October 2017 By Tim Newman Fact checked by Jasmin Collier According to a recent study, although treating major depressive disorder has benefits in the short-term, over a longer period of time, it may make the condition worse. Major depressive disorder is a serious, debilitating mental illness. In the United States, it affects […]

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Medscape: Depression in CAD Trumps All Other Risk Factors for Death

Medscape: Depression in CAD Trumps All Other Risk Factors for Death

  Patrice Wendling August 03, 2017 MURRAY, UT — Depression and coronary artery disease are known to walk hand in hand, but a new study suggests that depression any time after a diagnosis of CAD is the strongest predictor of death[1]. Among 24,137 patients identified with significant CAD, a new depression diagnosis was associated with a twofold higher risk […]

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Time Magazine Gives Cover Story to Ketamine

Time Magazine Gives Cover Story to Ketamine

New Hope for Depression Mandy Oaklander Jul 26, 2017 TIME Health For more, visit TIME Health. Every week, when Ian Hanley sits down with his therapist, he goes through a list of depression treatments he’s been researching online. The best-known treatments at the top of the list–half a dozen antidepressants and known combinations of those drugs–are […]

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TMS in Reuters: California Doctors Hope to ‘rewire’ Depression with TMS

TMS in Reuters: California Doctors Hope to ‘rewire’ Depression with TMS

LOS ANGELES, July 11 — Doctors in California say magnetic stimulation can help ‘rewire’ the brains of people withdepression, offering hope for patients whose condition is not improved by medication or therapy. Depression is one of the most common forms of mental illness, affecting more than 350 million people worldwide. Bob Holmes is one of […]

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Shape Magazine: Could Ketamine Help Cure Depression?

Shape Magazine: Could Ketamine Help Cure Depression?

Shape Magazine Recently Covered Ketamine as a Depression Treatment By Rachel Jacoby Zoldan | May 16, 2017 Depression is more common than you might think. It affects more than 15 million Americans, and the World Health Organization estimates that number grows to 300 million when you expand globally. There are a slew of different treatment […]