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Ketamine as a Treatment for Postpartum Depression

Ketamine as a Treatment for Postpartum Depression

Abstract Postpartum depression (PPD) affects over 10% of new mothers and adversely impacts the health of offspring. One of the greatest risk factors for PPD is prepregnancy stress but the underlying biological mechanism is unknown. Here we constructed an animal model which recapitulated prepregnancy stress induced PPD and tested the role of Akt-mTOR signaling in […]

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Ketamine Found Effective for Patients With Anxious Treatment-Resistant Depression

Ketamine Found Effective for Patients With Anxious Treatment-Resistant Depression

Patients with anxious depression—major depressive disorder (MDD) with high levels of anxiety—are known to have a poorer response to commonly used antidepressants than those with MDD. A small study published in Depression & Anxiety now suggests intravenous (IV) ketamine may be able to reduce symptoms in patients with anxious depression. The study found patients with and without anxious depression […]

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Is the Ketamine Boom Getting out of Hand? A Response.

Is the Ketamine Boom Getting out of Hand? A Response.

On September 26 2018 Scientific American published an article calling out some of the business practices being used by ketamine treatment providers across the country. The article summarized legitimate concerns about the business side of the ketamine while reiterating the promise ketamine shows as a breakthrough treatment for difficult to treat cases of depression. “This […]

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A Deeper Understanding of Major Depressive Disorder is Within Reach

A Deeper Understanding of Major Depressive Disorder is Within Reach

WHY AREN’T SOME PATIENTS WITH MDD REACHING REMISSION? For more than 50 years, major depressive disorder (MDD) pharmacological treatment approaches have focused on increasing the level of monoamine neurotransmitters in the brain, with the hope of reducing symptoms.1 And while conventional antidepressants have helped most, the STAR*D trial* found that one-third of patients didn’t achieve remission after multiple treatment […]

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The Glutamate Hypothesis in Synaptic Connectivity

Glutamate neurotransmission is an active area of research in major depressive disorder (MDD).1 Much of this interest revolves around glutamate’s role in regulating synaptic connectivity, one of several pathways that may strengthen and initiate the formation of new synaptic connections.1 As research advances, a deeper understanding of MDD is within reach. Watch our video featuring Dr […]

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Intranasal Esketamine Succeeds in Depression Trial

Intranasal Esketamine Succeeds in Depression Trial

4-point cut in MADRS scores versus placebo after 4 weeks by Kristen Monaco, Staff Writer, MedPage TodayMay 09, 2018 NEW YORK CITY — Intranasal esketamine paired with an oral antidepressant improved symptoms of treatment-resistant depression, researchers reported here. When compared to intranasal placebo plus an antidepressant, two phase III studies found twice-weekly flexibly-dosed intranasal esketamine added to […]

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Ketamine: A depression drug that researchers have called ‘the most important discovery in half a century’ just got a big lift

Ketamine: A depression drug that researchers have called ‘the most important discovery in half a century’ just got a big lift

Ketamine, which has been called “the most important discovery in half a century,” just got a step closer to becoming the first new depression drug in 35 years. Johnson & Johnson, one of the pharmaceutical companies pursuing the drug’s fast-acting antidepressant qualities, presented some promising new research on Saturday that could raise the drug’s profile as a potential treatment for […]