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Why and How Does Ketamine Work When Other Antidepressants Don’t?

Why and How Does Ketamine Work When Other Antidepressants Don’t?

Ketamine the Next-Gen Treatment “There are key questions right now concerning both the scientific understanding of ketamine and the potential future use of ketamine or ketamine-like drugs for depression,” Dr Murrough told Medscape Medical News. One question is how ketamine triggers an antidepressant response within 1 day, whereas conventional antidepressants require 2 weeks or longer to […]

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Ketamine Featured in the Globe and Mail: Offers New Hope for Patients with Severe Depression

Ketamine Featured in the Globe and Mail: Offers New Hope for Patients with Severe Depression

WENCY LEUNG The Globe and Mail Published Thursday, Feb. 16, 2017 3:23PM EST Last updated Thursday, Feb. 16, 2017 5:18PM EST Inspired by promising research into ketamine’s therapeutic effects, people are swapping strategies online on how to use the drug to ease their despair. Could ‘Special K’ be a panacea for depression? Wency Leung reports […]

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Ketamine Featured on DrugTargetReview.com

Ketamine Featured on DrugTargetReview.com

How Ketamine Could Cure Depression The major excitatory neurotransmitter in the central and peripheral nervous system, glutamic acid, has been known for more than 50 years to produce its actions through various ionotropic channels (NMDA and AMPA) and G-coupled metabotropic receptors (mGluR 1 to 5). The glutamate-sensitive ion channels comprise multiple protein subunits and are subject […]

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When Is Depression ‘Treatment Resistant’?

When Is Depression ‘Treatment Resistant’?

When should you, the prescriber, conclude that your patient with depression is “treatment resistant,” and thereby eligible for alternative non-pharmacological interventions—such as vagus nerve stimulation (VNS), electroconvulsive therapy (ECT), or transcranial magnetic stimulation (TMS)? There are multiple ways that the failure to agree on a standardized definition of treatment-resistant depression (TRD) impacts the clinical care […]